中文名稱

Farnesyl Thiosalicylic Acid (1 mg)

英文名字

FTS|Salirasib, Farnesyl Thiosalicylic Acid, 2-[[(2E,6E)-3,7,11-trimethyl-2,6,1-dodecatrien-1-yl]thio]-benzoic acid

供應(yīng)商

Cayman

產(chǎn)品貨號

10010501-1

產(chǎn)品報價

￥84/1 mg

產(chǎn)品說明書

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購買方式

產(chǎn)品新聞

背景資料

Association of Ras protein with the inner surface of the plasma membrane is required for Ras signaling activity. Farnesyl thiosalicylic acid -FTS) is an inhibitor of Ras-mediated signaling that functions by dislodging Ras from the cell membrane thereby rendering it susceptible to proteolytic degradation. FTS inhibits the growth of human Ha-ras-transformed Rat1 fibroblasts with an IC50 value of 7.5 uM. It does not inhibit Ras farnesylation in vitro and although FTS does inhibit prenylated protein methyltransferase -PPMTase) in cell-free systems with a Ki value of 2.6 uM, it is relatively ineffective at inhibiting methylation in whole cells. Treatment of chow-fed ApoE-deficient mice with 5 mg/kg FTS three times per week for six weeks reduces early atherosclerotic lesion development by 52% compared to controls.

產(chǎn)品描述

An inhibitor of Ras-mediated signaling that functions by dislodging Ras from the cell membrane thereby rendering it susceptible to proteolytic degradation; inhibits the growth of human Ha-ras-transformed Rat1 fibroblasts with an IC50 value of 7.5 uM

產(chǎn)品形式

保存建議

-20

其他

Cayman Chemical

注意

該頁面的中文產(chǎn)品信息的翻譯，僅供參考。準(zhǔn)確的產(chǎn)品信息請以廠家的英文說明書為準(zhǔn)。下單前，請瀏覽說明書確認(rèn)。

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