中文名稱

14,15-Leukotriene E4 (500 ug)

英文名字

Eoxin E4|EXE4|14,15-LTE4, 14,15-Leukotriene E4, 15S-hydroxy-14R-(S-cysteinyl)-5Z,8Z,1E,12E-eicosatetraenoic acid

供應商

Cayman

產(chǎn)品貨號

10011362-500

產(chǎn)品報價

￥23968/500 ug

產(chǎn)品說明書

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產(chǎn)品新聞

背景資料

Leukotrienes -LTs) are a group of acute inflammatory mediators derived from arachidonic acid in leukocytes. The majority of these metabolites are formed through the 5-lipoxygenase -5-LO) pathway. 14,15-LTE4 is a metabolite of 14,15-LTC4 and 14,15-LTD4, an alternate class of LTs synthesized by a pathway involving the dual actions of 15- and 12-LOs on arachidonic acid via 15-HpETE and 14,15-LTA4 intermediates. These metabolites are classified as eoxins because they are formed mostly by eosinophils. Mast cells and nasal polyps can synthesize 14,15-LTC4 as well, however metabolism to 14,15-LTE4 in these cells and tissue has not been documented. 14,15-LTE4 increases vascular permeability of human endothelial cell monolayers with about 10-fold less potency compared LTC4, but approximately 100-fold greater potency than histamine.

產(chǎn)品描述

A metabolite of 14,15-LTC4 and 14,15-LTD4 increases vascular permeability of human endothelial cell monolayers with about 10-fold less potency compared LTC4, but approximately 100-fold greater potency than histamine

產(chǎn)品形式

保存建議

-80

其他

Cayman Chemical

注意

該頁面的中文產(chǎn)品信息的翻譯，僅供參考。準確的產(chǎn)品信息請以廠家的英文說明書為準。下單前，請瀏覽說明書確認。

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