中文名稱

CAY10595 (50 mg)

英文名字

CAY10595, 5-chloro-1

供應(yīng)商

Cayman

產(chǎn)品貨號(hào)

10012553-50

產(chǎn)品報(bào)價(jià)

￥24500/50 mg

產(chǎn)品說明書

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產(chǎn)品新聞

背景資料

The biological effects of prostaglandin D2 -PGD2) are transduced by at least two 7-transmembrane G protein-coupled receptors, designated DP1 and CRTH2/DP2. In humans, CRTH2/DP2 is expressed on Th2 cells, eosinophils, and basophils where it mediates the chemotactic activity of PGD2. CAY10595, as a racemic mixture, is a potent CRTH2/DP2 receptor antagonist that binds to the human receptor with a Ki value of 10 nM. The R-enantiomer of CAY10595 is significantly more potent exhibiting Ki values of 5.3 and 5 nM at the human and murine CRTH2/DP2 receptor, respectively. The R- enantiomer of CAY10595 inhibits eosinophil chemotaxis induced by 13,14-dihydro-15-keto-PGD2 with an IC50 value of 7.3 nM.

產(chǎn)品描述

A potent CRTH2/DP2 receptor antagonist that binds to the human receptor with a Ki value of 10 nM; R enantiomer of CAY10595 inhibits eosinophil chemotaxis induced by 13,14-dihydro-15-keto-PGD2 with an IC50 value of 7.3 nM

產(chǎn)品形式

保存建議

-20

其他

Cayman Chemical

注意

該頁面的中文產(chǎn)品信息的翻譯，僅供參考。準(zhǔn)確的產(chǎn)品信息請(qǐng)以廠家的英文說明書為準(zhǔn)。下單前，請(qǐng)瀏覽說明書確認(rèn)。

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