中文名稱

CAY10607 (25 mg)

英文名字

BHI|Benzisoxazole Hsp9 Inhibitor, CAY10607, 4-chloro-6-[5-[[2-(4-morpholinyl)ethyl]amino]-1,2-benzisoxazol-3-yl]-1,3-benzenediol

供應(yīng)商

Cayman

產(chǎn)品貨號(hào)

10012694-25

產(chǎn)品報(bào)價(jià)

￥24010/25 mg

產(chǎn)品說(shuō)明書(shū)

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背景資料

Heat shock protein 90 -Hsp90) is a molecular chaperone that modulates intracellular signaling and protein folding, trafficking, and turnover. Inhibitors of Hsp90, such as geldanamycin, have shown promise as anti-tumor agents. CAY10607 binds the N-terminal domain of Hsp90, efficiently displacing geldanamycin from the ATP binding site -IC50 = 30 nM). In addition, CAY10607 inhibits the proliferation of several cancer cell lines -IC50 ~ 0.28 uM), promotes the degradation of the Hsp90 client proteins Her-2 and androgen receptor, and has no effect on a variety of kinases.

產(chǎn)品描述

Binds the N-terminal domain of Hsp90, efficiently displacing geldanamycin from the ATP binding site -IC50 = 30 nM); inhibits the proliferation of several cancer cell lines -IC50 ~ 0.28 uM), promotes the degradation of Hsp90 client proteins, and has no effect on a variety of kinases

產(chǎn)品形式

保存建議

-20

其他

Cayman Chemical

注意

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