Anti-Human Angiopoietin-1 / Ang-1-Anti-Human Angiopoietin-1 / Ang-1代理/參數(shù)/廠家-一抗-艾美捷科技有限公司

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背景資料: Angiopoietin1 (Ang1) and Angiopoietin2 (Ang2) are two closely related secreted ligands which bind with similar affinity to Tie2, a receptor tyrosine kinase with immunoglobulin and epidermal growth factor homology domains expressed primarily on endothelial cells and early hematopoietic cells. Tie2 and angiopoietins have been shown to play critical roles in embryogenic angiogenesis and in maintaining the integrity of the adult vasculature. Ang1 cDNA encodes a 498 amino acid (aa) residue precursor protein that contains a coiledcoiled domain near the aminoterminus and a fibrinogen like domain at the Cterminus. Human Ang 1 shares approximately 97% and 60% aa sequence identity with mouse Ang1 and human Ang2, respectively. Ang1 activates Tie2 signaling on endothelial cells to promote chemotaxis, cell survival, cell sprouting, vessel growth and stabilization. Ang2 has alternatively been reported to be an antagonist for Ang1 induced Tie2 signaling as well as an agonist for Tie2 signaling, depending on the cell context.

反應(yīng)性: 該Anti-Human Angiopoietin-1 / Ang-1的詳細(xì)信息查看ReliaTech提供的產(chǎn)品說明書。

保存建議: 該Anti-Human Angiopoietin-1 / Ang-1的詳細(xì)信息查看ReliaTech提供的產(chǎn)品說明書。溶解建議：Centrifuge vial prior to opening. Reconstitute the antibody with 500 μl sterile PBS and the final concentration is 200 μg/ml.

其他: ReliaTech全稱為受體配體技術(shù)有限公司 (Receptor Ligand Technologies GmbH)，1999年成立，總部位于德國不倫瑞克，是一家后基因組生物技術(shù)公司。ReliaTech主要專注于受體和配體的發(fā)現(xiàn)與研究。此外，ReliaTech也開發(fā)應(yīng)用于血管與淋巴管生成研究的相關(guān)高品質(zhì)試劑。目前ReliaTech提供近2800款產(chǎn)品，產(chǎn)品線主要包括重組蛋白(細(xì)胞因子、生長因子、可溶性受體)、抗體、ELISA試劑盒等。