Anti-Human MMP-8-Anti-Human MMP-8代理/參數(shù)/廠(chǎng)家-一抗-艾美捷科技有限公司

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背景資料: Matrix metalloproteinases (MMPs) are a family of zinc and calcium dependent endopeptidases with the combined ability to degrade all the components of the extracellular matrix. MMP8 (neutrophil collagenase) is expressed in neutrophils, where it is stored in specific granules. MMP8 release from the neutrophils is stimulated by various factors such as interleukins 1 and 8, TNFα and GM-CSF. MMP8 is capable of cleaving types I, II and III triplehelical collagen, gelatin peptides, fibronectin, proteoglycans, aggrecan, serpins, βcasein and peptides such as angiotensin and substance P. In addition to its function in phagocytosis, MMP8 has a high capacity for infiltrating connective tissue, and is implicated in the breakdown of the extracellular matrix in diseases such as rheumatoid arthritis. Structurally, MMP8 consists of several domains: a prodomain that is cleaved upon activation, a catalytic domain containing the zinc-binding site, a short hinge region and a hemopexinlike domain. MMP8 is heavily glycosylated.

保存建議: 該Anti-Human MMP-8的詳細(xì)信息查看ReliaTech提供的產(chǎn)品說(shuō)明書(shū)。溶解建議：Centrifuge vial prior to opening. Reconstitute the antibody with 500 μl sterile PBS and the final concentration is 200 μg/ml.

其他: ReliaTech全稱(chēng)為受體配體技術(shù)有限公司 (Receptor Ligand Technologies GmbH)，1999年成立，總部位于德國(guó)不倫瑞克，是一家后基因組生物技術(shù)公司。ReliaTech主要專(zhuān)注于受體和配體的發(fā)現(xiàn)與研究。此外，ReliaTech也開(kāi)發(fā)應(yīng)用于血管與淋巴管生成研究的相關(guān)高品質(zhì)試劑。目前ReliaTech提供近2800款產(chǎn)品，產(chǎn)品線(xiàn)主要包括重組蛋白(細(xì)胞因子、生長(zhǎng)因子、可溶性受體)、抗體、ELISA試劑盒等。

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