MMP12, also known as macrophage elastase, is a zinc and calcium dependent endopeptidase expressed constitutively in macrophages and can be induced in monocytes. MMP12 can degrade a broad spectrum of substrates, including type IV collagen, fibronectin, laminin, vitronectin, proteoglycans, chondroitin sulfate, myelin basic protein, α-1antitrypsin, and plasminogen. It can also activate MMP2 and MMP-3. The MMP12 precursor consists of a pro domain, a catalytic domain containing the zinc-binding site, and a C-terminal hemopexin like domain.
應(yīng)用類型
WB, IHC (P)
免疫原
該Anti-Human MMP-12的詳細信息查看ReliaTech提供的產(chǎn)品說明書。
來源宿主
該Anti-Human MMP-12的詳細信息查看ReliaTech提供的產(chǎn)品說明書。
反應(yīng)性
該Anti-Human MMP-12的詳細信息查看ReliaTech提供的產(chǎn)品說明書。
保存建議
該Anti-Human MMP-12的詳細信息查看ReliaTech提供的產(chǎn)品說明書。溶解建議:Centrifuge vial prior to opening. Reconstitute the antibody with 500 μl sterile PBS and the final concentration is 200 μg/ml.