Anti-Human BMP-5-Anti-Human BMP-5代理/參數(shù)/廠家-一抗-艾美捷科技有限公司

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中文名稱: Anti-Human BMP-5

英文名字: Anti-Human BMP-5

供應(yīng)商: ReliaTech

產(chǎn)品貨號: 101-M236

產(chǎn)品報價: ￥詢價/100ug

產(chǎn)品說明書: 點擊查看

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背景資料: Bone Morphogenetic Protein5 (BMP5) is one of at least 15 structurally and functionally related BMPs which are members of the transforming growth factor β (TGFβ) superfamily. BMP5 is synthesized as a 454 amino acid (aa) precursor protein that is cleaved at the dibasic cleavage site (RxxR) to release the 20 kDa Cterminal mature protein. Mature BMP5 contains seven conserved cysteine residues involved in formation of the cysteine knot and the single interchain disulfide bond. Biologically active BMP5 is a disulfidelinked homodimer of the C-terminal mature protein. Mature human BMP 5 shares 96% aa sequence identity with mouse and rat BMP5. Cellular responses to BMP5 are mediated by the formation of heterooligomeric complexes of type I and type II serine/threonine kinase receptors. BMP5 is expressed by chondrocytes in proliferating and hypertrophic zones of bone growth plates. It contributes to limb development by promoting proliferation and differentiation of chondrocytes as well as apoptosis of undifferentiated mesoderm. Genetic defects in BMP5 which cause Cterminal truncation or loss of the proteolytic cleavage site result in multiple skeletal abnormalities, including the short ear phenotype in mice. BMP5 is also expressed by ovarian granulosa cells where it functions as an autocrine factor to promote GC proliferation and inhibit their production of progesterone. In the nervous system, BMP5 promotes dendrite outgrowth and dopaminergic neuronal differentiation. It is upregulated in oral squamous carcinoma cells and induces apoptosis of some myeloma cell lines.

應(yīng)用類型: WB

免疫原: 該Anti-Human BMP-5的詳細信息查看ReliaTech提供的產(chǎn)品說明書。

來源宿主: 該Anti-Human BMP-5的詳細信息查看ReliaTech提供的產(chǎn)品說明書。

反應(yīng)性: 該Anti-Human BMP-5的詳細信息查看ReliaTech提供的產(chǎn)品說明書。

保存建議: 該Anti-Human BMP-5的詳細信息查看ReliaTech提供的產(chǎn)品說明書。溶解建議：Centrifuge vial prior to opening. Reconstitute the antibody with 500 μl sterile PBS and the final concentration is 200 μg/ml.

其他: ReliaTech全稱為受體配體技術(shù)有限公司 (Receptor Ligand Technologies GmbH)，1999年成立，總部位于德國不倫瑞克，是一家后基因組生物技術(shù)公司。ReliaTech主要專注于受體和配體的發(fā)現(xiàn)與研究。此外，ReliaTech也開發(fā)應(yīng)用于血管與淋巴管生成研究的相關(guān)高品質(zhì)試劑。目前ReliaTech提供近2800款產(chǎn)品，產(chǎn)品線主要包括重組蛋白(細胞因子、生長因子、可溶性受體)、抗體、ELISA試劑盒等。