The FGF family is comprised of at least seven polypeptides that are potent regulators of cell proliferation, differentiation and function. All FGFs have two conserved cysteine residues and share 30-50% sequence homology at the amino acid level. FGF5 was originally identified as a transforming gene by the NIH3T3 focus formation assay using DNA derived from human tumors. FGF5 cDNA encodes a 267 amino acid residue protein with a putative 22 amino acid residue signal peptide. The murine homologue of FGF5 was cloned and found to be 84% homologous to the human protein at the amino acid sequence level. Human and murine FGF5 exhibit cross species activity. In vitro, recombinant human FGF5 is a mitogen for Balb/3T3 fibroblasts and bovine heart endothelial cells. FGF5 was also reported to be a major muscle-derived survival factor for cultured spinal moto-neurons.
應用類型
WB, IHC (P)
免疫原
該Anti-Human FGF-5的詳細信息查看ReliaTech提供的產品說明書。
來源宿主
該Anti-Human FGF-5的詳細信息查看ReliaTech提供的產品說明書。
反應性
該Anti-Human FGF-5的詳細信息查看ReliaTech提供的產品說明書。
保存建議
該Anti-Human FGF-5的詳細信息查看ReliaTech提供的產品說明書。溶解建議:Centrifuge vial prior to opening. Reconstitute the antibody with 500 μl sterile PBS and the final concentration is 200 μg/ml.