Members of the Trk family (TrkA, B, and C) of receptor tyrosine kinases act as receptors for the neurotrophin family: BDNF, NGF, NT-3, and NT-4. Trks exhibit selectivity for specific neurotrophins. TrkA, TrkB and TrkC preferentially bind NGF, NT-4 and BDNF, and NT-3, respectively. All Trk family proteins share a common structural organization consisting of an extracellular region with two cysteine-rich domains, a cluster of three leucine-rich motifs, and two immunoglobulin-like domains, and an intracellular region that contains the tyrosine kinase domain. They are best known for their regulation of neuronal survival and axon outgrowth.
應用類型
WB, IHC (F)
免疫原
該Anti-Human Trk-B的詳細信息查看ReliaTech提供的產品說明書。
來源宿主
該Anti-Human Trk-B的詳細信息查看ReliaTech提供的產品說明書。
反應性
該Anti-Human Trk-B的詳細信息查看ReliaTech提供的產品說明書。
保存建議
該Anti-Human Trk-B的詳細信息查看ReliaTech提供的產品說明書。溶解建議:Centrifuge vial prior to opening. Reconstitute the antibody with 500 μl sterile PBS and the final concentration is 200 μg/ml.