Anti-Human AGGF1-Anti-Human AGGF1代理/參數(shù)/廠家-一抗-艾美捷科技有限公司

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中文名稱: Anti-Human AGGF1

英文名字: Anti-Human AGGF1

供應(yīng)商: ReliaTech

產(chǎn)品貨號(hào): 102-PA13

產(chǎn)品報(bào)價(jià): ￥詢價(jià)/200ug

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背景資料: AGGF1, also known as VG5Q, was identified by its association with Klippel Trenaunay syndrome (KTS), a congenital vascular morphogenesis disorder (1 3). AGGF1 is expressed by vascular endothelial cells in many tissues (1). It appears to be secreted and promotes endothelial cell proliferation following interactions with endothelial cell surfaces (1). AGGF1 also directly interacts with TWEAK (1), a TNF superfamily ligand with angiogenic properties (8). It was shown that AGGF1 is involved in establishing venous identity in zebrafish embryos. Overexpression of AGGF1 led to increased angiogenesis and increased lumen diameter of veins, whereas knockdown of AGGF1 expression resulted in defective vasculogenesis and angiogenesis. Overexpression of AGGF1 increased expression of venous markers (e.g. VEGFR-3/FLT4), but had little effect on arterial markers (e.g. Notch5). Knockdown of AGGF1 expression resulted in a loss of venous identity (loss of expression of VEGFR-3/FLT4, Ephb4 and Dab2), but had no effect on the expression of arterial development. It was further shown that AGGF1 activates AKT, and that decreased AGGF1 expression inhibits AKT activation. Overexpression of constitutively active AKT rescues the loss of venous identity caused by AGGF1 downregulation. These results indicate that AGGF might be an angiogenic factor with an important role in the specification of vein identity and suggests that AGGF1-mediated AKT signaling is responsible for establishing venous cell fate.

應(yīng)用類型: WB, IHC

免疫原: 該Anti-Human AGGF1的詳細(xì)信息查看ReliaTech提供的產(chǎn)品說明書。

來源宿主: Rabbit

反應(yīng)性: 該Anti-Human AGGF1的詳細(xì)信息查看ReliaTech提供的產(chǎn)品說明書。

保存建議: 該Anti-Human AGGF1的詳細(xì)信息查看ReliaTech提供的產(chǎn)品說明書。

其他: ReliaTech全稱為受體配體技術(shù)有限公司 (Receptor Ligand Technologies GmbH)，1999年成立，總部位于德國(guó)不倫瑞克，是一家后基因組生物技術(shù)公司。ReliaTech主要專注于受體和配體的發(fā)現(xiàn)與研究。此外，ReliaTech也開發(fā)應(yīng)用于血管與淋巴管生成研究的相關(guān)高品質(zhì)試劑。目前ReliaTech提供近2800款產(chǎn)品，產(chǎn)品線主要包括重組蛋白(細(xì)胞因子、生長(zhǎng)因子、可溶性受體)、抗體、ELISA試劑盒等。