The antibody is specific for a combinatorial determinate of integrin α4β7complex. Integrin α4β7 is composed of a 150 kD (α4 or CD49d) and a 130 kD (β7) heterodimer, also known as CD49d/β7 or LPAM-1. Belonging to the Ig superfamily, it is found on the majority of peripheral lymphocytes and subsets of thymocytes and bone marrow cells (including mast cell progenitors). Integrin α4β7 binds its ligands, VCAM-1 (CD106), MAdCAM-1 and fibronectin, and plays an important role in lymphocytes adhesion and the direction of migration of blood lymphocytes to the intestine and associated lymphoid tissues.
應(yīng)用類型
IHC (P), FC, IP
免疫原
該Anti-Mouse LPAM-1的詳細信息查看ReliaTech提供的產(chǎn)品說明書。
來源宿主
該Anti-Mouse LPAM-1的詳細信息查看ReliaTech提供的產(chǎn)品說明書。
反應(yīng)性
該Anti-Mouse LPAM-1的詳細信息查看ReliaTech提供的產(chǎn)品說明書。
保存建議
該Anti-Mouse LPAM-1的詳細信息查看ReliaTech提供的產(chǎn)品說明書。溶解建議:Centrifuge vial prior to opening. Reconstitute the antibody with 500 μl sterile PBS and the final concentration is 200 μg/ml.