Anti-Mouse Endocan/ESM-1-Anti-Mouse Endocan/ESM-1代理/參數(shù)/廠家-一抗-艾美捷科技有限公司

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中文名稱: Anti-Mouse Endocan/ESM-1

英文名字: Anti-Mouse Endocan/ESM-1

供應(yīng)商: ReliaTech

產(chǎn)品貨號: 103-M221

產(chǎn)品報價: ￥詢價/100ug

產(chǎn)品說明書: 點擊查看

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背景資料: Endocan (endothelial cell proteoglycan), also known as endothelialcell specific molecule1 (ESM-1), is a 50 kDa monomeric, secreted, cysteinerich proteoglycan identified initially in endothelial cells of the kidney and lung. Mouse Endocan is synthesized as a 184 amino acid (aa) precursor that contains a 21 aa signal sequence and a 20 kDa, 163 aa mature region. The N-terminal 2/3 of the molecule contains 18 cysteine residues and there are no potential N-linked glycosylation sites. Based on human Endocan, there are at least two potential O-linked glycosylation sites, one of which will likely be utilized on Ser at position # 136 of the mature molecule. The posttranslational modification is approximately 30 kDa in size. It consists of a single dermatan sulfate chain that contains 4O sulfated N-acetyl galactosamine with αiduronate. This chain is suggested to bind HGF and contribute to HGF mitogenic activity. Mature mouse Endocan shares 96% and 74% aa identity with rat and human Endocan, respectively. In human, there is a potential for an alternate splice variant. It shows a deletion of aa 82-131, a range which would not remove the dermatan sulfate attachment site. It is not known if such a splice form exists in mouse. Endocan is expressed by endothelial cells, adipocytes, bronchial epithelium and distal renal tubular epithelium. It is upregulated by TNFα and VEGF, and is known to bind to LFA1 (integrin αLβ2) on the surface of PBMCs, blocking LFA1 interaction with ICAM1. Normal circulating levels of Endocan are approximately 1 ng/mL.

應(yīng)用類型: WB

免疫原: 該Anti-Mouse Endocan/ESM-1的詳細信息查看ReliaTech提供的產(chǎn)品說明書。

來源宿主: 該Anti-Mouse Endocan/ESM-1的詳細信息查看ReliaTech提供的產(chǎn)品說明書。

反應(yīng)性: 該Anti-Mouse Endocan/ESM-1的詳細信息查看ReliaTech提供的產(chǎn)品說明書。

保存建議: 該Anti-Mouse Endocan/ESM-1的詳細信息查看ReliaTech提供的產(chǎn)品說明書。溶解建議：Centrifuge vial prior to opening. Reconstitute the antibody with 500 μl sterile PBS and the final concentration is 200 μg/ml.

其他: ReliaTech全稱為受體配體技術(shù)有限公司 (Receptor Ligand Technologies GmbH)，1999年成立，總部位于德國不倫瑞克，是一家后基因組生物技術(shù)公司。ReliaTech主要專注于受體和配體的發(fā)現(xiàn)與研究。此外，ReliaTech也開發(fā)應(yīng)用于血管與淋巴管生成研究的相關(guān)高品質(zhì)試劑。目前ReliaTech提供近2800款產(chǎn)品，產(chǎn)品線主要包括重組蛋白(細胞因子、生長因子、可溶性受體)、抗體、ELISA試劑盒等。