Anti-Mouse Desert Hedgehog (N-terminal)-Anti-Mouse Desert Hedgehog (N-terminal)代理/參數(shù)/廠家-一抗-艾美捷科技有限公司

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中文名稱: Anti-Mouse Desert Hedgehog (N-terminal)

英文名字: Anti-Mouse Desert Hedgehog (N-terminal)

供應(yīng)商: ReliaTech

產(chǎn)品貨號(hào): 103-M287

產(chǎn)品報(bào)價(jià): ￥詢價(jià)/100ug

產(chǎn)品說明書: 點(diǎn)擊查看

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背景資料: Desert Hedgehog (Dhh) belongs to the highly conserved Hedgehog family of proteins which are involved in multiple developmental processes. Hedgehogs are synthesized as 45 kDa precursors that are cleaved autocatalytically. The 19 kDa Nterminal fragment remains membrane associated due to its cholesterol and palmitate modifications. Binding of this fragment to Patched receptors results in the loss of Patched repression of Smoothened signaling. Dhh binds both Patched and Patched 2 as well as Hedgehog interacting protein (Hip). Within the N-terminal peptide, mouse Dhh shares 97% and 100% amino acid (aa) sequence identity with human and rat Dhh, respectively. It shares 74% aa seqeuence identity with mouse Indian (Ihh) and Sonic hedgehog (Shh). Dhh is produced by Sertoli cells and is required for testis development and spermatogenesis. It induces steroidogenic factor 1 which is instrumental in promoting Leydig cell differentiation. It also promotes the deposition of basal lamina surrounding seminiferous tubules. In humans, mutations of Dhh are associated with pure gonadal dysgenesis. Dhh is expressed in the female by ovarian granulosa cells and the corpus luteum. Its upregulation in human ovarian cancer correlates positively with proliferative index and negatively with prognosis. Dhh is also expressed by Schwann cells and is upregulated following nerve injury. It induces the expression of Patched and Hip in nerve fibroblasts and promotes the formation of the connective tissue sheath surrounding peripheral nerves.

應(yīng)用類型: WB, IHC (P)

免疫原: 該Anti-Mouse Desert Hedgehog (N-terminal)的詳細(xì)信息查看ReliaTech提供的產(chǎn)品說明書。

來源宿主: 該Anti-Mouse Desert Hedgehog (N-terminal)的詳細(xì)信息查看ReliaTech提供的產(chǎn)品說明書。

反應(yīng)性: 該Anti-Mouse Desert Hedgehog (N-terminal)的詳細(xì)信息查看ReliaTech提供的產(chǎn)品說明書。

保存建議: 該Anti-Mouse Desert Hedgehog (N-terminal)的詳細(xì)信息查看ReliaTech提供的產(chǎn)品說明書。溶解建議：Centrifuge vial prior to opening. Reconstitute the antibody with 500 μl sterile PBS and the final concentration is 200 μg/ml.

其他: ReliaTech全稱為受體配體技術(shù)有限公司 (Receptor Ligand Technologies GmbH)，1999年成立，總部位于德國(guó)不倫瑞克，是一家后基因組生物技術(shù)公司。ReliaTech主要專注于受體和配體的發(fā)現(xiàn)與研究。此外，ReliaTech也開發(fā)應(yīng)用于血管與淋巴管生成研究的相關(guān)高品質(zhì)試劑。目前ReliaTech提供近2800款產(chǎn)品，產(chǎn)品線主要包括重組蛋白(細(xì)胞因子、生長(zhǎng)因子、可溶性受體)、抗體、ELISA試劑盒等。