ALS (Acid labile subunit) is an 84-86 kDa glycoprotein member of the leucine rich repeat superfamily of molecules. It is secreted by hepatocytes in response to growth hormone stimulation, and forms a 140-150 kDa ternary complex with IGFBP3 (or IGFBP5) and IGFI. This complex increases the half-life of IGFI and retains it in the circulation for use in multiple tissues. Mature mouse ALS is 580 amino acids (aa) in length (aa 24-603). It contains twentyone 20-23 aa LRRs that participate in proteinprotein interactions. There are two potential isoform variants that show N-terminal extensions. One contains a 66 aa substitution for aa 1 -5, while another possesses an 89 aa substitution again for aa 15. Over aa 28-603, mouse ALS shares 79% and 93% aa identity with human and rat ALS, respectively.
該Anti-Mouse ALS的詳細(xì)信息查看ReliaTech提供的產(chǎn)品說明書。溶解建議:Centrifuge vial prior to opening. Reconstitute the antibody with 500 μl sterile PBS and the final concentration is 200 μg/ml.