Anti-Mouse Angiopoietin-like protein 3-Anti-Mouse Angiopoietin-like protein 3代理/參數(shù)/廠家-一抗-艾美捷科技有限公司

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中文名稱: Anti-Mouse Angiopoietin-like protein 3

英文名字: Anti-Mouse Angiopoietin-like protein 3

供應(yīng)商: ReliaTech

產(chǎn)品貨號: 103-M307

產(chǎn)品報價: ￥詢價/100ug

產(chǎn)品說明書: 點擊查看

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背景資料: ANGPTL3 is a secreted glycoprotein that is structurally related to the angiopoietins.Mature mouse ANGPTL3 contains an N-terminal coiled coil domain and a C-terminal fibrinogen like domain. ANGPTL3 is expressed in the liver from early in development through adulthood. Full length ANGPTL3 circulates in the plasma as do the proteolytically separated Nand C-terminal fragments containing the coiled coil domain and fibrinogenlike domains, respectively. ANGPTL3 is found as 70 kDa, 50 kDa, and 32 kDa species and can form weakly associated noncovalent multimers in vitro. ANGPTL3 directly inhibits lipoprotein lipase (LPL), an enzyme responsible for hydrolyzing circulating triglycerides. This activity requires a putative heparinbinding motif that is N-terminal to the coiled coil domain. Proteolytic removal of the fibrinogenlike domain from the N-terminal fragment serves to activate ANGPTL3 and increase its ability to inhibit LPL in vitro and function in vivo. ANGPTL3 promotes an increase in circulating triglyceride levels without altering VLDL or HDL secretion or uptake. ANGPTL3 knockoutmice are hypolipidemic and have elevated LPL activity. ANGPTL3 expression in vivo is upregulated by LXR agonists and downregulated by insulin, leptin, and TRβ agonists. Dysregulated ANGPTL3 expression and elevated plasma triglyceride levels are characteristic of some strains of obese and diabetic mice, ANGPTL3 does not bind Tie1 or Tie2 but its fibrinogenlike domain interacts with integrin αVβ3 to induce endothelial cell adhesion, migration, and neovascularization. ANGPTL3, secreted by fetal liver cells, also promotes the expansion of hematopoietic stem cells. Mature mouse ANGPTL3 shares 22%-30% amino acid (aa) sequence identity with ANGPTL 1, 2, 4, 6, and 7. It shares 77% aa sequence identity with human ANGPTL3.

應(yīng)用類型: ELISA

免疫原: 該Anti-Mouse Angiopoietin-like protein 3的詳細信息查看ReliaTech提供的產(chǎn)品說明書。

來源宿主: 該Anti-Mouse Angiopoietin-like protein 3的詳細信息查看ReliaTech提供的產(chǎn)品說明書。

反應(yīng)性: 該Anti-Mouse Angiopoietin-like protein 3的詳細信息查看ReliaTech提供的產(chǎn)品說明書。

保存建議: 該Anti-Mouse Angiopoietin-like protein 3的詳細信息查看ReliaTech提供的產(chǎn)品說明書。溶解建議：Centrifuge vial prior to opening. Reconstitute the antibody with 500 μl sterile PBS and the final concentration is 200 μg/ml.

其他: ReliaTech全稱為受體配體技術(shù)有限公司 (Receptor Ligand Technologies GmbH)，1999年成立，總部位于德國不倫瑞克，是一家后基因組生物技術(shù)公司。ReliaTech主要專注于受體和配體的發(fā)現(xiàn)與研究。此外，ReliaTech也開發(fā)應(yīng)用于血管與淋巴管生成研究的相關(guān)高品質(zhì)試劑。目前ReliaTech提供近2800款產(chǎn)品，產(chǎn)品線主要包括重組蛋白(細胞因子、生長因子、可溶性受體)、抗體、ELISA試劑盒等。