Anti-Mouse Epigen-Anti-Mouse Epigen代理/參數(shù)/廠家-一抗-艾美捷科技有限公司

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中文名稱: Anti-Mouse Epigen

英文名字: Anti-Mouse Epigen

供應商: ReliaTech

產(chǎn)品貨號: 103-M379

產(chǎn)品報價: ￥詢價/100ug

產(chǎn)品說明書: 點擊查看

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背景資料: Epigen (EPGN) is an epithelial mitogen that belongs to the EGF superfamily. Mouse Epigen cDNA encodes a 152 amino acid (aa) residue type I transmembrane precursor protein with a 23 aa putative signal peptide, an 86 aa extracellular domain, a 21 aa transmembrane domain and a 22 aa cytoplasmic domain. The extracellular domain (aa 24-109) contains a pattern of six cysteines typical of EGF family proteins. Epigen is among several EGF family proteins that can undergo metalloproteinase cleavage to generate a soluble form. Cleavage of Epigen by TACE/ADAM17 has been demonstrated. The mature, shed form of mouse Epigen (aa 53-103) shares 92%, 96% and 90% aa sequence identity with human, rat and equine Epigen, respectively, and more than 40% aa identity with corresponding regions of TGFα and epiregulin. Epigen mRNA is found in many tissues, but it is mainly expressed in actively proliferating cells within these tissues. For example, Epigen in skin is found mainly in the proliferating root sheath of hair follicles, and transgenic overexpression in the skin causes hyperplasia in sebaceous glands. Epigen is also expressed developmentally and by invasive adenocarcinomas of the breast and prostate. Epigen is strongly mitogenic for epithelial cells and fibroblasts, despite its relatively weak affinity for its main receptor, ErbB1. The mitogenic potential of Epigen is enhanced by its unusually long persistence on the membrane before ubiquitylation and receptor-mediated-depletion.

應用類型: WB

免疫原: 該Anti-Mouse Epigen的詳細信息查看ReliaTech提供的產(chǎn)品說明書。

來源宿主: 該Anti-Mouse Epigen的詳細信息查看ReliaTech提供的產(chǎn)品說明書。

反應性: 該Anti-Mouse Epigen的詳細信息查看ReliaTech提供的產(chǎn)品說明書。

保存建議: 該Anti-Mouse Epigen的詳細信息查看ReliaTech提供的產(chǎn)品說明書。溶解建議：Centrifuge vial prior to opening. Reconstitute the antibody with 500 μl sterile PBS and the final concentration is 200 μg/ml.

其他: ReliaTech全稱為受體配體技術有限公司 (Receptor Ligand Technologies GmbH)，1999年成立，總部位于德國不倫瑞克，是一家后基因組生物技術公司。ReliaTech主要專注于受體和配體的發(fā)現(xiàn)與研究。此外，ReliaTech也開發(fā)應用于血管與淋巴管生成研究的相關高品質(zhì)試劑。目前ReliaTech提供近2800款產(chǎn)品，產(chǎn)品線主要包括重組蛋白(細胞因子、生長因子、可溶性受體)、抗體、ELISA試劑盒等。