Anti-Mouse MBL-2-Anti-Mouse MBL-2代理/參數(shù)/廠家-一抗-艾美捷科技有限公司

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中文名稱: Anti-Mouse MBL-2

英文名字: Anti-Mouse MBL-2

供應(yīng)商: ReliaTech

產(chǎn)品貨號: 103-M434

產(chǎn)品報價: ￥詢價/100ug

產(chǎn)品說明書: 點擊查看

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背景資料: Mannan binding lectin (MBL) belongs to the collectin family of innate immune defense proteins, which binds to an array of carbohydrate patterns on pathogen surfaces. Collectin family members share common structural features: a cysteine rich aminoterminal domain, a collagen like region, an α helical-coiled-coil neck domain and a carboxy terminal Ctype (Ca ++dependent) lectin or carbohydrate recognition domain (CRD). MBL homotrimerizes to form a structural unit joined by Nterminal disulfide bridges. These homotrimers further associates into oligomeric structures of up to 6 units. Whereas two forms of MBL proteins (MBL1, also known as SMBP or MBLA and MBL2, also known as LMBP or MBLC) exist in rodents and other animals, only one functional MBL protein is present in humans. Mouse MBL2 shares approximately 52% and 60% aa sequence identity with mouse MBL1 and human MBL, respectively. In mouse, MBL1 and MBL2 are the only collectins that can activate complement via the lectin complement pathway. Serum oligomeric MBL associates with MBL-associated serine protease (MASP) proenzymes. The MBLMASP proenzyme complex preferentially interact with sugar patterns containing mannose, glucose, L-fucose, or N-acetylglucosamine present at a terminal nonreducing postion on the cell surface of various pathogens and certain tumor cells. This interaction induces proenzyme activation and the triggering of the complement cascade, resulting in opsonization and pathogen removal via humoral and cellular immune responses. MBL does not recognize selfcomponents or glycoproteins from other higher animals due to the presence of terminal sialic acid or galactose that interrupts the repeating carbohydrate structures. A number of membrane receptors for MBL, including C1q phagocytic receptor (C1qRp), calreticulin (also known as C1qR), and CR1 (CD35), have been described. Interactions with these receptors may also be important in stimulating phagocytosis. Mouse MBL 1 and MBL2 are produced primarily in the liver and are secreted into the blood stream. In addition, mouse MBL1 is also expressed in lung, kidney, and testis while MBL2 is expressed in kidney, thymus, and small intestine.

應(yīng)用類型: WB

免疫原: 該Anti-Mouse MBL-2的詳細信息查看ReliaTech提供的產(chǎn)品說明書。

來源宿主: 該Anti-Mouse MBL-2的詳細信息查看ReliaTech提供的產(chǎn)品說明書。

反應(yīng)性: 該Anti-Mouse MBL-2的詳細信息查看ReliaTech提供的產(chǎn)品說明書。

保存建議: 該Anti-Mouse MBL-2的詳細信息查看ReliaTech提供的產(chǎn)品說明書。溶解建議：Centrifuge vial prior to opening. Reconstitute the antibody with 500 μl sterile PBS and the final concentration is 200 μg/ml.

其他: ReliaTech全稱為受體配體技術(shù)有限公司 (Receptor Ligand Technologies GmbH)，1999年成立，總部位于德國不倫瑞克，是一家后基因組生物技術(shù)公司。ReliaTech主要專注于受體和配體的發(fā)現(xiàn)與研究。此外，ReliaTech也開發(fā)應(yīng)用于血管與淋巴管生成研究的相關(guān)高品質(zhì)試劑。目前ReliaTech提供近2800款產(chǎn)品，產(chǎn)品線主要包括重組蛋白(細胞因子、生長因子、可溶性受體)、抗體、ELISA試劑盒等。