Anti-Mouse Persephin-Anti-Mouse Persephin代理/參數(shù)/廠家-一抗-艾美捷科技有限公司

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中文名稱: Anti-Mouse Persephin

英文名字: Anti-Mouse Persephin

供應(yīng)商: ReliaTech

產(chǎn)品貨號(hào): 103-M453

產(chǎn)品報(bào)價(jià): ￥詢價(jià)/100ug

產(chǎn)品說(shuō)明書(shū): 點(diǎn)擊查看

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背景資料: Persephin is a secreted protein belonging to the glial cell linederived neurotrophic factor (GDNF) family of the TGFβ superfamily. It shares 3846% amino acid identity with family members GDNF, neurturin and artemin. Persephin is expressed at very low levels in most tissues. The 10-12 kDa mature protein contains several cysteines that are conserved among family members. It circulates as an unglycosylated disulfidelinked homodimer. Mature mouse persephin shares 94%, 81%, 79% and 76% amino acid sequence identity with rat, human, bovine and canine persephin, respectively. Like other GDNF family members, persephin acts through engagement of a glycosylphosphatidylinositol (GPI) linked GDNF receptor family (GRF) member that signals through the receptor tyrosine kinase RET. Persephin is reported to promote both the survival and growth of central dopaminergic and motor neurons, and kidney development. These effects are correlated with the expression patterns of its specific receptor, GFRα4, and RET. Functional GFRα4 isoforms are found only in thyroid, adrenal medulla and portions of the central nervous system and include GPI linked, transmembrane and soluble forms. In vitro, persephin promotes survival only in neurons which coexpress GPIlinked GFRα4 with RET. This effect does not show a strong correlation to the recruitment of RET in lipid rafts seen with other GDNF family members. Disruption of the persephin gene results in mice that are morphologically normal but have more damage and less effective repair after a central nervous system insult simulating a stroke.

應(yīng)用類型: WB

免疫原: 該Anti-Mouse Persephin的詳細(xì)信息查看ReliaTech提供的產(chǎn)品說(shuō)明書(shū)。

來(lái)源宿主: 該Anti-Mouse Persephin的詳細(xì)信息查看ReliaTech提供的產(chǎn)品說(shuō)明書(shū)。

反應(yīng)性: 該Anti-Mouse Persephin的詳細(xì)信息查看ReliaTech提供的產(chǎn)品說(shuō)明書(shū)。

保存建議: 該Anti-Mouse Persephin的詳細(xì)信息查看ReliaTech提供的產(chǎn)品說(shuō)明書(shū)。溶解建議：Centrifuge vial prior to opening. Reconstitute the antibody with 500 μl sterile PBS and the final concentration is 200 μg/ml.

其他: ReliaTech全稱為受體配體技術(shù)有限公司 (Receptor Ligand Technologies GmbH)，1999年成立，總部位于德國(guó)不倫瑞克，是一家后基因組生物技術(shù)公司。ReliaTech主要專注于受體和配體的發(fā)現(xiàn)與研究。此外，ReliaTech也開(kāi)發(fā)應(yīng)用于血管與淋巴管生成研究的相關(guān)高品質(zhì)試劑。目前ReliaTech提供近2800款產(chǎn)品，產(chǎn)品線主要包括重組蛋白(細(xì)胞因子、生長(zhǎng)因子、可溶性受體)、抗體、ELISA試劑盒等。