中文名稱

MLL1/WAR complex -human recombinant) (250 ug)

英文名字

Mixed-Lineage Leukemia-1|MLL Core Complex, MLL1/WAR complex -human recombinant)

供應(yīng)商

Cayman

產(chǎn)品貨號(hào)

10756-250

產(chǎn)品報(bào)價(jià)

￥19446/250 ug

產(chǎn)品說明書

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背景資料

The MLL complex methylates histone 3 at lysine 4 -H3K4) to upregulate transcription. MLL1 is the catalytic subunit which exhibits a low basal methyltransferase activity. Addition of WDR5, Ash2L, and RbBP5 -WAR) enhances Histone H3K4 methylation 300-fold; an additional 2-fold activation has been reported for the addition of DPY-30 -Item No. 11178 and Item No. 10945). The MLL core complex colocalizes with RNA Polymerase II on chromosomes and is involved in the transition of paused Pol II to actively-transcribing Pol II. Misregulation of MLL1 by fusion of its non-catalytic N-terminus to any of >50 other proteins leads to leukemia, possibly due to release of paused Pol II at developmentally important sites such as the Hox family of genes. Wild-type MLL1 is targeted to Hox genes through interactions with menin, and is thus important for proper development.,The Cayman MLL1/WAR complex is supplied as four tubes. Combining the four tubes will result in an equimolar ratio of MLL1, WDR5, Ash2L, and RbBP5.

產(chǎn)品描述

Source: Active recombinant proteins expressed in E. coli

產(chǎn)品形式

保存建議

-80

其他

Cayman Chemical

注意

該頁面的中文產(chǎn)品信息的翻譯，僅供參考。準(zhǔn)確的產(chǎn)品信息請(qǐng)以廠家的英文說明書為準(zhǔn)。下單前，請(qǐng)瀏覽說明書確認(rèn)。

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