- 中文名稱
CAY10651 (10 mg)
- 英文名字
- CAY10651, 3-fluoro-5-(2-methylbenzo(d)thiazol-5-yl)-benzonitrile
- 供應(yīng)商
- Cayman
- 產(chǎn)品貨號
- 10820-10
- 產(chǎn)品報(bào)價(jià)
- ￥3360/10 mg
- 產(chǎn)品說明書
- 點(diǎn)擊查看
- 購買方式
- 產(chǎn)品新聞
- 背景資料
- Glutamate, the major excitatory neurotransmitter in the CNS, signals through both ionotropic and metabotropic glutamate receptors. Of the eight metabotropic glutamate receptors -mGlus) discovered thus far, development of inhibitors to mGlu5 has been given significant attention in preclinical models of disease, including pain, anxiety, gastresophageal reflux disease, Parkinson s associated dyskinesia, and fragile X syndrome, as well as in animal models of drug addiction. CAY10651 is a noncompetitive antagonist -negative allosteric modulator) of mGlu5 that demonstrates an IC50 value of 61 nM in a calcium mobilization assay and a Ki value of 477 nM in a radioligand binding assay. A 10 uM concentration of CAY10651 results in a near complete blockade of the glutamate response in cortical astrocytes. A 30 mg/kg dose of CAY10651 in mice yields potent inhibition in a marble burying model of anxiety and is efficacious in an operant sensation seeking model of addiction.
- 產(chǎn)品描述
- A noncompetitive antagonist of mGlu5 -IC50 = 61 nM; Ki = 477 nM); 10 uM results in a near complete blockade of the glutamate response in cortical astrocytes; 30 mg/kg in mice yields potent inhibition in a marble burying model of anxiety and is efficacious in an operant sensation seeking model of addiction
- 產(chǎn)品形式
- 保存建議
- -20
- 其他
- Cayman Chemical
- 注意
-
該頁面的中文產(chǎn)品信息的翻譯，僅供參考。準(zhǔn)確的產(chǎn)品信息請以廠家的英文說明書為準(zhǔn)。下單前，請瀏覽說明書確認(rèn)。
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