中文名稱

MLL1/WARD complex -human recombinant) (2 x 250 ug)

英文名字

KMT2A|Mixed-Lineage Leukemia-1|MLL Core Complex, MLL1/WARD complex -human recombinant)

供應(yīng)商

Cayman

產(chǎn)品貨號(hào)

10945-2

產(chǎn)品報(bào)價(jià)

￥36400/2 x 250 ug

產(chǎn)品說(shuō)明書

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購(gòu)買方式

產(chǎn)品新聞

背景資料

The MLL complex methylates histone 3 at lysine 4 -H3K4) to upregulate transcription. MLL1 is the catalytic subunit and contains the core components WDR5, Ash2L, and RbBP5 -MLL/WAR complex). MLL1 alone exhibits a low basal methyltransferase activity, but is enhanced 300-fold by the addition of the WAR components. A further 2-fold activation has been reported with the addition of DPY-30 -MLL/WARD complex). The MLL core complex colocalizes with RNA Polymerase II on chromosomes and is involved in the transition of paused Pol II to actively-transcribing Pol II. Misregulation of MLL1 by fusion of its non-catalytic N-terminus to any of >50 other proteins leads to leukemia, possibly due to release of paused Pol II at developmentally important sites such as the Hox family of genes. Wild-type MLL1 is targeted to Hox genes through interactions with menin, and is thus important for proper development.,The Cayman MLL1/WARD complex with DPY-30 is supplied as five tubes. Combining the five tubes will result in an equimolar ratio of MLL1, WDR5, Ash2L, and RbBP5. DPY-30, which binds Ash2L as a heterodimer, will be in a two molar excess of the MLL1/WAR components.

產(chǎn)品描述

Source: Active recombinant proteins expressed in E. coli

產(chǎn)品形式

保存建議

-80

其他

Cayman Chemical

注意

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