15-deoxy-.DELTA.12,14-PGD2 is a synthetic analog of PGD2 and a potential precursor to the PPAR.gamma. ligand 15-deoxy-.DELTA.12,14-PGJ2. It possesses cytotoxic effects on L1210 mouse leukemia cells in vitro with an IC50 of 0.3 ug/ml. 15-deoxy-.DELTA.12,14-PGD2 is 10-fold more potent than PGD2 in this activity. However, it is a less effective inhibitor of ADP-induced platelet aggregation -IC50 = 320 ng/ml) compared to PGD2 -IC50 = 3 ng/ml).
產(chǎn)品描述
15-deoxy-.DELTA.12,14-PGD2 is a synthetic analog of PGD2 and a potential precursor to the PPAR.gamma. ligand 15-deoxy-.DELTA.12,14-PGJ2.{1424} It possesses cytotoxic effects on L1210 mouse leukemia cells in vitro with an IC50 of 0.3 ug/ml. 15-deoxy-.DELTA.12,14-PGD2 is 10-fold more potent than PGD2 in this activity.{334} However, it is a less effective inhibitor of ADP-induced platelet aggregation -IC50 = 320 ng/ml) compared to PGD2 -IC50 = 3 ng/ml).{1139}