Iloprost is a second generation structural analog of prostacyclin -PGI2) with about ten-fold greater potency than the first generation stable analogs, typified by carbaprostacyclin. Iloprost binds with equal affinity to the recombinant human IP and EP1 receptors with a Ki value of 11 nM. Most preparations of iloprost contain 16-S) and 16-R) stereoisomers. 16-S)-Iloprost potently inhibits platelet aggregation with an IC50 value of 3.5 nM.
產(chǎn)品描述
An isomer of iloprost that potently inhibits platelet aggregation with an IC 50 value of 3.5 nM