中文名稱

--)-AS 115 (5 mg)

英文名字

--)-AS 115, 2-fluorophenyl-(2-(((1R,2S)-2-(butoxymethyl)cyclohexyl)methoxy)ethyl)carbamate

供應(yīng)商

Cayman

產(chǎn)品貨號(hào)

13250-5

產(chǎn)品報(bào)價(jià)

￥21070/5 mg

產(chǎn)品說明書

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背景資料

KIAA1363 is a 2-acetyl monoacylglyceryl ether -MAGE) hydrolase that is upregulated in aggressive cancers from various tissues. The enzyme catalyzes the hydrolysis of the 2-acetyl MAGE to MAGE and serves as a central enzyme in the PAF and LPA signaling network. AS 115 is a potent and selective inactivator of KIAA1363, displaying an IC50 value of 150 nM when tested as a racemic mixture in the invasive ovarian cancer cell line SK0V-3. Treatment of SKOV-3 cells with 10 uM AS-115 for 4 hours significantly reduced the formation of MAGE, alkyl-lysophosphatidylcholine, and alkyl-lysophosphatidic acid. The activity of the individual enantiomers of AS 115, i.e. -+)-AS 115 and --)-AS 115, has not been determined.

產(chǎn)品描述

A single enantiomer of a potent and selective inactivator of KIAA1363, a MAGE hydrolase an enzyme that is upregulated in addressive cancers from various tissues -IC50 = 150 nM when tested as a racemic mixture in SK0V-3 cells); activity of the individual enantiomers of AS 115, i.e. -+)-AS 115 and --)-AS 115, has not been determined

產(chǎn)品形式

保存建議

-20

其他

Cayman Chemical

注意

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