中文名稱

N-methyl Leukotriene C4 (500 ug)

英文名字

N-methyl LTC4, N-methyl Leukotriene C4, N-methyl-5S-hydroxy-6R-(S-glutathionyl)-7E,9E,11Z,14Z-eicosatetraenoic acid

供應(yīng)商

Cayman

產(chǎn)品貨號(hào)

13390-500

產(chǎn)品報(bào)價(jià)

￥30016/500 ug

產(chǎn)品說(shuō)明書(shū)

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產(chǎn)品新聞

背景資料

Produced by neutrophils, macrophages, mast cells, and by transcellular metabolism in platelets, leukotriene C4 -LTC4) is the parent cysteinyl leukotriene formed by the LTC4 synthase-catalyzed conjugation of glutathione to LTA4. It is one of the constituents of slow-reacting substance of anaphylaxis -SRS-A) and exhibits potent smooth muscle contracting activity. LTC4, however, is rapidly metabolized to LTD4 and LTE4, which makes the characterization of LTC4 pharmacology difficult. N-methyl LTC4 is a synthetic analog of LTC4 that is not readily metabolized to LTD4 and LTE4.It acts as a potent and selective CysLT2 receptor agonist exhibiting EC50 values of 122 and > 2,000 nM at the human CysLT2 and CysLT1 receptors, respectively. It has essentially the same potency as LTC4 at both the human and murine receptors CysLT2 receptors. N-methyl LTC4 is potent and active in vivo, causing vascular leak in mice overexpressing the human CysLT2 receptor but not in CysLT2 receptor knockout mice.

產(chǎn)品描述

A stable analog of LTC4 that does not readily metabolize to LTD4 and LTE4 at the expense of marginally reduced biological activity

產(chǎn)品形式

保存建議

-80

其他

Cayman Chemical

注意

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