- 中文名稱
AFP 07 -free acid) (10 mg)
- 英文名字
- AFP 07 -free acid), 5Z-[(3aR,4R,5R,6aS)-3,3-difluorohexahydro-5-hydroxy-4-[(1E,3S,4S)-3-hydroxy-4-methyl-1-nonen-6-ynyl]-2H-cyclopenta[b]furan-2-ylidene]-pentanoic acid
- 供應商
- Cayman
- 產品貨號
- 13626-10
- 產品報價
- ￥19208/10 mg
- 產品說明書
- 點擊查看
- 購買方式
- 產品新聞
- 背景資料
- Prostaglandin I2 is an unstable prostanoid which, through the I prostanoid -IP) receptor, inhibits platelet aggregation and promotes vasodilatation in pulmonary vascular beds. AFP 07 is a 7,7-difluoroprostacyclin derivative that acts as a selective and highly potent agonist for the IP receptor -Ki = 0.561 nM). AFP 07 shows weaker affinity for EP receptors, with Ki values > 100 nM for EP1-3 and > 10 nM for EP4. In piglet and rabbit saphenous veins, which express both IP and EP4, the EP4 antagonist AH 23848 reduces AFP 07-mediated relaxation, suggesting that AFP 07 activates EP4 as well as IP, particularly when both receptors are present.
- 產品描述
- A 7,7-difluoroprostacyclin derivative that acts as a selective and highly potent agonist for the IP receptor -Ki = 0.561 nM); shows weaker affinity for EP receptors, with Ki values > 100 nM for EP1-3 and > 10 nM for EP4
- 產品形式
- 保存建議
- -20
- 其他
- Cayman Chemical
- 注意
-
該頁面的中文產品信息的翻譯，僅供參考。準確的產品信息請以廠家的英文說明書為準。下單前，請瀏覽說明書確認。
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