Abacavir is metabolized in cells to carbovir triphosphate, a potent, selective inhibitor of HIV reverse transcriptase -Ki = 21 nM). Abacavir is relatively non-toxic to human bone marrow progenitor cells -IC50 = 110 uM). It penetrates the blood-brain barrier and resistance to abacavir has been shown to develop relatively slowly.
產(chǎn)品描述
Metabolized in cells to carbovir triphosphate, a potent, selective inhibitor of HIV reverse transcriptase -Ki = 21 nM); relatively non-toxic to human bone marrow progenitor cells -IC50 = 110 uM)