中文名稱

20-ethyl Prostaglandin E2 (50 mg)

英文名字

2-ethyl PGE2, 20-ethyl Prostaglandin E2, 9-oxo-11.alpha.,15S-dihydroxy-2a,2b-dihomoprosta-5Z,13E-dien-1-oic acid

供應(yīng)商

Cayman

產(chǎn)品貨號

14940-50

產(chǎn)品報價

￥22540/50 mg

產(chǎn)品說明書

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產(chǎn)品新聞

背景資料

20-ethyl Prostaglandin E2 -20-ethyl PGE2) is an analog of PGE2 in which the .omega.-chain has been extended by the addition of two methylene carbon atoms. The only well studied prostaglandin analog with this structural feature is unoprostone, an F-series prostaglandin that is clinically approved as a glaucoma medication. Unoprostone also contains lower side chain modifications -13,14-dihydro-15-keto) which severely limit its affinity for FP receptors, contributing to its lack of potency as a medication. 20-ethyl PGE2 retains the natural 15-S) allylic hydroxyl in the lower side chain, which may improve its potency relative to unoprostone. However, ligand binding assays of this analog with respect to EP or other prostanoid receptors have not been published. E-type prostaglandins have been widely reported to have inflammatory, cytoprotective, and a variety of other effects.

產(chǎn)品描述

20-ethyl PGE2 is an analog of PGE2 in which the .omega.-chain has been extended by the addition of two methylene carbon atoms. The only well studied prostaglandin analog with this structural feature is unoprostone, an F-series prostaglandin that is clinically approved as a glaucoma medication.{8147} Unoprostone also contains lower side chain modifications -13,14-dihydro-15-keto) which severely limit its affinity for FP receptors, contributing to its lack of potency as a medication. 20-ethyl PGE2 retains the natural 15-S) allylic hydroxyl in the lower side chain, which may improve its potency relative to unoprostone. However, ligand binding assays of this analog with respect to EP or other prostanoid receptors have not been published. E-type prostaglandins have been widely reported to have inflammatory,{5381} cytoprotective,{2216} and a variety of other effects.{1558}

產(chǎn)品形式

保存建議

-20

其他

Cayman Chemical

注意

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