紅霉素(5毫克)產(chǎn)品是Potent inhibitor of yeast NAD?-dependent histone deacetylase Sir2p (IC?? = 60 uM). Sensitizes mammalian cells to a variety of DNA-damaging agents by abrogating Sir2p activity on p53. Acts by either altering or blocking access to the acetylated histone binding pocket.