蘋(píng)果酸舒尼替尼(持續(xù)性)(25毫克)產(chǎn)品是Sunitinib is a potent inhibitor of CSF-1 receptor kinase in an enzyme assay, with an IC?? of 7 nM, and inhibits receptor phosphorylation in a cellular assay with an IC?? of 61 nM. Sunitinib inhibits SCF-induced phosphotyrosine levels on KIT (IC?? = 1 - 10 nM) and reduced SCF-stimulated ERK1/2 phosphorylation with an IC?? value consistent with that for inhibition of KIT phosphotyrosine levels. Sunitinib also inhibited SCF-stimulated proliferation in NCI-H526 cells (IC?? = 2 nM).