SIRT1抑制劑,EX-527(10毫克)產(chǎn)品是A potent SIRT1 inhibitor (IC?? = 38 nM). EX-527 is 200-500-fold more selective for SIRT1 than for SIRT2 or SIRT3. Does not inhibit SIRT4-7, does not inhibit class I/II HDAC activity at concentrations up to 100uM. Enhances p53 acetylation in response to DNA damaging agents.