SB-431542(5毫克)產(chǎn)品是A potent and selective inhibitor of the TGF-β1 receptor ALK5 (IC?? = 94 nM). It inhibits ALK4 only at higher concentrations (IC?? = 140 nM). Suppresses renewal in embryonic and induced pluripotent stem (iPS) cells and promotes their differentiation through its effect on Smad signaling pathway.