L-JNKI1陰性對照肽(1 mg)產(chǎn)品是Cell-permeable. A potent and selective inhibitor of Akt1/Akt2 activity (IC?? = 58 nM (Akt1), 210 nM (Akt2) and 2.12 uM (Akt3) in in vitro kinase assays). The inhibition appears to be pleckstrin homology (PH) domain-dependent. It does not exhibit any inhibitory effect against PH domain-lacking Akts, or other closely related AGC family kinases, PKA, PKC, and SGK, even at concentrations (50 uM).