巴非霉素A1(50微克)產(chǎn)品是A highly potent and selective inhibitor of vacuolar H?-ATPases (V-ATPases) in vitro. It is effective in nanomolar concentrations in animal cells, plant cells and microorganisms; also selective over other ATP hydrolyzing enzymes such as F-ATPases, Ca2?-ATPases, Na?/K?-ATPases and plasma membrane H?-ATPases. Also prevents autophagy at a late stage by inhibiting fusion between autophagosomes and lysosomes.