MK-2206(500 ug)產(chǎn)品是A highly selective non-ATP competitive allosteric Akt inhibitor with IC??’s of 8 nM, 2 nM and 65 nM for Akt1, Akt2 and Akt3, respectively. MK-2206 potently inhibits phosphorylation of Thr3?? and Ser??3 in 3T3-L1 adipocytes with IC?? values of 0.11 and 0.18 uM, respectively as well as downstream effects of insulin on GLUT4 translocation (IC?? = 0.47 uM) and glucose transport (IC?? = 0.14 uM). In addition, treatment with MK-2206 causes a robust, concentration-dependent activation of autophagy in human glioma cell lines LN229 and T98G.