ML130(25毫克)產(chǎn)品是Cell-permeable. A selective NOD1 (nucleotide-binding oligomerization domain 1) inhibitor. Selectively inhibits NOD1-dependent activation of NF-kB in HEK293 cells (IC?? = 0.56±0.04 uM). Displays high selectivity (>36-fold) over MDP-stimulated signaling in reporter cell lines containing both endogenous and overexpressed NOD2 proteins or TNF-?-induced NF-kB activation.