【干冰】Anti-LEFTY A (MOUSE) Monoclonal Antibody - 200-301-279-【干冰】Anti-LEFTY A (MOUSE) Monoclonal Antibody

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背景資料: During vertebrate embryogenesis, a left-right axis is established.? Secreted growth factors of the TGF-beta family, including gene products derived from nodal, lefty-1 and lefty-2, play crucial roles in establishing left-right asymmetries.? TGF-beta (Transforming growth factor-beta) is a pleiotropic cytokine that regulates growth and differentiation of diverse types of cells. TGF-beta actions are directed by ligand-induced activation of TGF-beta receptors.?? Complexes formed move into the nucleus, where they act as components of a transcriptional complex.? Lefty, a novel member of the TGF-beta superfamily, inhibits TGF-beta signaling.? Lefty acts to inhibit phosphorylation of Smad2 following activation of the TGF-beta receptor.? Lefty also inhibits events downstream from R-Smad phosphorylation.? Lefty provides a repressed state of TGF-beta-responsive genes.? The Lefty family is comprised of Lefty 1 and Lefty 2 in mouse, and Lefty A and Lefty B in humans.? Members of the TGF-beta superfamily require processing for their activation.?? Cleavage is therefore an essential step for Lefty activation.? Lefty is synthesized as a large inactive precursor (42 Kda) that must be endoproteolytically processed to release the bioactive polypeptide (28 kDa and 34 kDa forms). The 28kDa form induces MAPK activity.

免疫原: A BALB/c mouse was immunized with a recombinant form of 6X HIS tagged human LEFTY.

保存建議: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

其他: Rockland成立于1962年，是一家老牌抗體原產(chǎn)企業(yè)，其位于美國(guó)費(fèi)城郊區(qū)的農(nóng)場(chǎng)保有近20種實(shí)驗(yàn)動(dòng)物。Rockland公司為生命科學(xué)領(lǐng)域提供豐富的、高質(zhì)量的抗體，包括載脂蛋白、細(xì)胞周期/凋亡、細(xì)胞因子、細(xì)胞信號(hào)蛋白、酶類、細(xì)胞外基質(zhì)、轉(zhuǎn)錄因子(NFkB)和泛素（Ubiquitin）等識(shí)別抗體，應(yīng)用范圍包括Western blot、免疫組化、免疫熒光和ELISA等。另外，Rockland也生產(chǎn)特別齊全的二抗，包括純化、生物素、HRP/ALP、熒光標(biāo)記二抗，應(yīng)用十分廣泛。