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中文名稱(chēng)

【干冰】Anti-MyD88 (MOUSE) Antibody - 200-301-CW6

英文名字
【干冰】Anti-MyD88 (MOUSE) Antibody - 200-301-CW6
供應(yīng)商
Rockland
產(chǎn)品貨號(hào)
200-301-CW6
產(chǎn)品報(bào)價(jià)
¥詢(xún)價(jià)/100ug
產(chǎn)品說(shuō)明書(shū)
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產(chǎn)品新聞
背景資料
The pro-inflammatory cytokine IL-1 induced cellular response requires IL-1 receptor complex including IL-1RI and IL-1RAcP. MyD88 has been identified as an adapter molecule in the IL-1 signaling pathway. MyD88 associates with and recruits IRAK to the IL-1 receptor complex in response to IL-1 treatment and dominant negative form of MyD88 attenuates IL-1R-mediated NF-kB activation. MyD88 is also employed as a regulator molecule by IL-18 receptor and human Toll receptor, which are members in the Toll/IL-1R family of receptors. Targeted disruption of the MyD88 gene results in lose of cellular responses to IL-1 and IL-18, and MyD88-deficient mice lack responses to bacterial product LPS that employs Toll-like receptors 2 and 4 (TLR2 and TLR4) as the signaling receptors. MyD88 is a general adapter protein for the Toll/IL-1R family of receptors and plays an important role in the inflammatory response induced by cytokines IL-1 and IL-18 and endotoxin. MyD88 gene is expressed in many tissues.
應(yīng)用類(lèi)型
ELISA,Immunohistochemistry,IF Microscopy,Western Blot,
免疫原
Anti-MyD88 antibody was produced in mice by repeated immunizations with a recombinant protein corresponding to amino acids 176 to 280 of human MyD88.
來(lái)源宿主
Mouse
反應(yīng)性
H. sapiens (Human); Mus musculus (Mouse)
保存建議
Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
其他
Rockland成立于1962年,是一家老牌抗體原產(chǎn)企業(yè),其位于美國(guó)費(fèi)城郊區(qū)的農(nóng)場(chǎng)保有近20種實(shí)驗(yàn)動(dòng)物。Rockland公司為生命科學(xué)領(lǐng)域提供豐富的、高質(zhì)量的抗體,包括載脂蛋白、細(xì)胞周期/凋亡、細(xì)胞因子、細(xì)胞信號(hào)蛋白、酶類(lèi)、細(xì)胞外基質(zhì)、轉(zhuǎn)錄因子(NFkB)和泛素(Ubiquitin)等識(shí)別抗體,應(yīng)用范圍包括Western blot、免疫組化、免疫熒光和ELISA等。另外,Rockland也生產(chǎn)特別齊全的二抗,包括純化、生物素、HRP/ALP、熒光標(biāo)記二抗,應(yīng)用十分廣泛。
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