【干冰】Anti-HSP90 (MOUSE) Monoclonal Antibody - 200-301-F67-【干冰】Anti-HSP90 (MOUSE) Monoclonal Antibody

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中文名稱: 【干冰】Anti-HSP90 (MOUSE) Monoclonal Antibody - 200-301-F67

英文名字: 【干冰】Anti-HSP90 (MOUSE) Monoclonal Antibody - 200-301-F67

供應商: Rockland

產(chǎn)品貨號: 200-301-F67

產(chǎn)品報價: ￥詢價/200ug

產(chǎn)品說明書: 點擊查看

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背景資料: Hsp90 is a highly conserved and essential stress protein that is expressed in all eukaryotic cells. From a functional perspective, hsp90 participates in the folding, assembly, maturation, and stabilization of specific proteins as an integral component of a chaperone complex. Despite its label of being a heat-shock protein, hsp90 is one of the most highly expressed proteins in unstressed cells (1–2% of cytosolic protein). It carries out a number of housekeeping functions – including controlling the activity, turnover, and trafficking of a variety of proteins. Most of the hsp90- regulated proteins that have been discovered to date are involved in cell signaling. The number of proteins now know to interact with Hsp90 is about 100. Target proteins include the kinases v-Src, Wee1, and c-Raf, transcriptional regulators such as p53 and steroid receptors, and the polymerases of the hepatitis B virus and telomerase.5 When bound to ATP, Hsp90 interacts with co-chaperones Cdc37, p23, and an assortment of immunophilin-like proteins, forming a complex that stabilizes and protects target proteins from proteasomal degradation. In most cases, hsp90-interacting proteins have been shown to co-precipitate with hsp90 when carrying out immunoadsorption studies, and to exist in cytosolic heterocomplexes with it. In a number of cases, variations in hsp90 expression or hsp90 mutation has been shown to degrade signaling function via the protein or to impair a specific function of the protein (such as steroid binding, kinase activity) in vivo. Ansamycin antibiotics, such as geldanamycin and radicicol, inhibit hsp90 function.

應用類型: Immunohistochemistry,Western Blot,

免疫原: Hsp90 Antibody was produced in mice by repeated immunizations raised against heat shock protein 90 from the water mold Achyla ambisexualis.

來源宿主: Mouse

反應性: Achyla; Gallus gallus (Chicken); H. sapiens (Human); Leporidae (Rabbit); Mus musculus (Mouse); Rattus (Rat); Sf9 cell line; Triticum aestivum (Wheat Germ)

保存建議: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

其他: Rockland成立于1962年，是一家老牌抗體原產(chǎn)企業(yè)，其位于美國費城郊區(qū)的農(nóng)場保有近20種實驗動物。Rockland公司為生命科學領域提供豐富的、高質量的抗體，包括載脂蛋白、細胞周期/凋亡、細胞因子、細胞信號蛋白、酶類、細胞外基質、轉錄因子(NFkB)和泛素（Ubiquitin）等識別抗體，應用范圍包括Western blot、免疫組化、免疫熒光和ELISA等。另外，Rockland也生產(chǎn)特別齊全的二抗，包括純化、生物素、HRP/ALP、熒光標記二抗，應用十分廣泛。