p23 is a highly conserved ubiquitous protein, known to have an important function as a cochaperone for the hsp90 chaperoning system. Studies have revealed that p23 is a small protein (18 to 25 kDa) with a simple structure. p23 does not have any structuralnhomology with any other known proteins. p23 was first discovered as a part of the Hsp90-progesterone receptor complex along with hsp70, p54 and p50. p23 is a phosphor-protein, which is highly acidic and has an aspartic acid-rich c-terminal domain. Numerous studies have found p23 to be associated with other client proteins like Fes tyrosine kinase, the heme regulated kinase HRI, hsf1 transcription factor, aryl hydrocarbon receptor, telomerase, and Hepadnavirus reverse transcriptase. In spite of several years of study, the exact functional significance of p23 is still not clear. p23 is thought to be involved in the adenosine triphosphate–mediated hsp90 binding of client proteins. Since many hsp90 client proteins are involved in oncogenic survival signaling, a recent study has concluded p23 to be a promising target in leukemic apoptosis. Hsp90 and its co-chaperone p23 are certainly among the emerging anti-tumor targets in oncology.
應(yīng)用類(lèi)型
ELISA,Western Blot,
免疫原
p23 Antibody was produced in mice by repeated immunizations raised against a recombinant human full length p23 protein.
來(lái)源宿主
Mouse
反應(yīng)性
Cavia porcellus (Guinea Pig); Gallus gallus (Chicken); H. sapiens (Human); Leporidae (Rabbit); Mus musculus (Mouse); Saccharomyces cerevisiae (Baker's yeast)
保存建議
Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.