【干冰】Anti-p38 alpha MAPKinase (MOUSE) Monoclonal Antibody - 200-301-G27-【干冰】Anti-p38 alpha MAPKinase (MOUSE) Monoclonal Antibody

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中文名稱: 【干冰】Anti-p38 alpha MAPKinase (MOUSE) Monoclonal Antibody - 200-301-G27

英文名字: 【干冰】Anti-p38 alpha MAPKinase (MOUSE) Monoclonal Antibody - 200-301-G27

供應商: Rockland

產(chǎn)品貨號: 200-301-G27

產(chǎn)品報價: ￥詢價/100ug

產(chǎn)品說明書: 點擊查看

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背景資料: The MAPK (mitogen activated protein kinase) comprises a family of ubiquitous praline-directed, proteinserine/threonine kinases which signal transduction pathways that control intracellular events including acute responses to hormones and major developmentalnchanges in organisms. This super family consists of stress activated protein kinases (SAPKs); extracellular signal-regulated kinases (ERKs); and p38 kinases, each of which forms a separate pathway. The kinase members that populate each pathway are sequentially activated by phosphorylation. Upon activation, p38 MAPK/SAPK2α translocates into the nucleus where it phosphorylates one or more nuclear substrates, effecting transcriptional changes and other cellular processes involved in cell growth, division, differentiation, inflammation, and death. Specifically p38 always acts as a pro-apoptotic factor with its activation leading to the release of cytochrome c from mitochondria and cleavage of caspase 3 and its downstream effector, PARP. p38 MAPK is activated by a variety of chemical stress inducers including hydrogen peroxide, heavy metals, anisomycin, sodium salicylate, LPS, and biological stress signals such as tumor necrosis factor, interleukin-1, ionizing and UV irradiation, hyperosmotic stress and chemotherapeuticndrugs. As a result, p38 alpha has been widely validated as a target for inflammatory disease including rheumatoid arthritis, COPD and psoriasis and has also been implicated in cancer, CNS and diabetes.

應用類型: ELISA,Immunoprecipitation,Western Blot,

免疫原: p38 Antibody was produced in mice by repeated immunizations raised against a full length recombinant protein expressed in E.coli cells.

來源宿主: Mouse

反應性: H. sapiens (Human)

保存建議: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

其他: Rockland成立于1962年，是一家老牌抗體原產(chǎn)企業(yè)，其位于美國費城郊區(qū)的農(nóng)場保有近20種實驗動物。Rockland公司為生命科學領(lǐng)域提供豐富的、高質(zhì)量的抗體，包括載脂蛋白、細胞周期/凋亡、細胞因子、細胞信號蛋白、酶類、細胞外基質(zhì)、轉(zhuǎn)錄因子(NFkB)和泛素（Ubiquitin）等識別抗體，應用范圍包括Western blot、免疫組化、免疫熒光和ELISA等。另外，Rockland也生產(chǎn)特別齊全的二抗，包括純化、生物素、HRP/ALP、熒光標記二抗，應用十分廣泛。