【干冰】Anti-MBD3 (MOUSE) Monoclonal Antibody - 200-301-H92-【干冰】Anti-MBD3 (MOUSE) Monoclonal Antibody

PRODUCT CENTER

一抗

產品中心

當前位置：首頁 > 產品中心 > 免疫學產品 > 一抗

中文名稱: 【干冰】Anti-MBD3 (MOUSE) Monoclonal Antibody - 200-301-H92

英文名字: 【干冰】Anti-MBD3 (MOUSE) Monoclonal Antibody - 200-301-H92

供應商: Rockland

產品貨號: 200-301-H92

產品報價: ￥詢價/100ug

產品說明書: 點擊查看

購買方式: 90%產品中國有現(xiàn)貨庫存。銀行轉賬、電匯、支票、現(xiàn)金，在線支付寶及網(wǎng)銀支付，或直接與我們電話聯(lián)系400-6800-868

產品新聞

背景資料: Anti-MBD3 Antibody detects human MBD3. DNA methylation, or the addition of methyl groups to cytosine bases in the dinucleotide CpG, is imperative to proper development and regulates gene expression. The methylation pattern involves the enzymatic processes of methylation and demethylation. The demethylation enzyme was recently found to be a mammalian protein, which exhibits demethylase activity associated to a methyl-CpG-binding domain (MBD). The enzyme is able to revert methylated cytosine bases to cytosines within the particular dinucleotide sequence mdCpdG by catalyzing the cleaving of the methyl group as methanol. MeCP2 and MBD1 (PCM1) are first found to repress transcription by binding specifically to methylated DNA. MBD2 and MBD4 (also known as MED1) were later found to colocalize with foci of heavily methylated satellite DNA and believed to mediate the biological functions of the methylation signal. Surprisingly, MBD3 does not bind methylated DNA both in vivo and in vitro. MBD1, MBD2, MBD3, and MBD4 are found to be expressed in somatic tissues, but the expression of MBD1 and MBD2 is reduced or absent in embryonic stem cells, which are known to be deficient in MeCP1 activity. MBD4 have homology to bacterial base excision repair DNA N-glycosylases/lyases. In some microsatellite unstable tumors MBD4 is mutated at an exonic polynucleotide tract. Anti-MBD3 Antibody is ideal for investigators involved in Epigenetic, DNA damage and repair, and cell cycle protein research.

應用類型: Western Blot,

免疫原: MBD3 Antibody was produced in mice prepared by repeated immunizations with human MBD3 along the internal region of the protein.

來源宿主: Mouse

反應性: H. sapiens (Human)

保存建議: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

其他: Rockland成立于1962年，是一家老牌抗體原產企業(yè)，其位于美國費城郊區(qū)的農場保有近20種實驗動物。Rockland公司為生命科學領域提供豐富的、高質量的抗體，包括載脂蛋白、細胞周期/凋亡、細胞因子、細胞信號蛋白、酶類、細胞外基質、轉錄因子(NFkB)和泛素（Ubiquitin）等識別抗體，應用范圍包括Western blot、免疫組化、免疫熒光和ELISA等。另外，Rockland也生產特別齊全的二抗，包括純化、生物素、HRP/ALP、熒光標記二抗，應用十分廣泛。