CD8 is a cell surface glycoprotein expressing on thymocytes subsets and cytotoxic T cells and is?either a homodimer of two alpha chains, or a heterodimer of one alpha and one beta chain. It acts as a coreceptor during T cell activation through the binding of MHC Class I molecules and is found?on T lymphocytes that mediates efficient cell-cell interactions within the immune system. CD8 associates with LCK with the help of a zinc clasp structure and down-regulates the production of?major Th2-type cytokines. CD8 is also known to recruit pUL97 thereby inducing dissolution of the nuclear lamina and facilitating the nuclear export of viral capsids.
應用類型
Flow Cytometry,
免疫原
Anti-CD8 Antibody (Monoclonal) was produced by repeated immunizations with CD8 antigen.
來源宿主
Mouse
反應性
H. sapiens (Human)
保存建議
Store vial at 4° C prior to opening.? This product is stable for several weeks at 4° C as an undiluted liquid.? Dilute only prior to immediate use.? DO NOT FREEZE. This product is light sensitive.