CD11b is a 165-170 kD type I transmembrane glycoprotein also known as αM integrin, Mac-1, CR3, and C3biR. CD11b non-covalently associates with integrin β2 (CD18) and is expressed on granulocytes, monocytes/macrophages, dendritic cells, NK cells, and subsets of T and B cells. CD11b/CD18 is critical for the transendothelial migration of monocytes and neutrophils. It is also involved in granulocyte adhesion, phagocytosis, and neutrophil activation. CD11b/CD18 interacts with ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4, CD14, CD23, heparin, iC3b, fibrinogen, and Factor X.
應(yīng)用類型
Flow Cytometry,IF Microscopy,Immunoprecipitation,
免疫原
Anti-CD11b Antibody (Monoclonal) was produced by repeated immunizations with CD11b antigen.
來源宿主
Mouse
反應(yīng)性
H. sapiens (Human)
保存建議
Store vial at 4° C prior to opening.? This product is stable for several weeks at 4° C as an undiluted liquid.? Dilute only prior to immediate use.? DO NOT FREEZE. This product is light sensitive.