CD40 is a 48 kD type I glycoprotein also known as BP50. It is a member of the TNFR superfamily primarily expressed on B cells, macrophages, follicular dendritic cells, endothelial cells, fibroblasts, and at low levels on plasma cells. CD40 has been reported to be involved in B cell differentiation, costimulation, isotype class-switching, and protection of B cells from apoptosis. Additionally, CD40 is important for T cell-B cell interactions. The ligand of CD40 is CD154 (CD40 ligand). The 5C3 antibody has been reported to promote B cell proliferation in the presence of anti-IgM, IL-4 or PMA, partially blocking CD40 binding to CD40L, and B cells rescue from apoptosis.
應(yīng)用類(lèi)型
Flow Cytometry,
免疫原
Anti-CD40 Antibody (Monoclonal) was produced by repeated immunizations with CD40 antigen.
來(lái)源宿主
Mouse
反應(yīng)性
H. sapiens (Human)
保存建議
Store vial at 4° C prior to opening.? This product is stable for several weeks at 4° C as an undiluted liquid.? Dilute only prior to immediate use.? DO NOT FREEZE. This product is light sensitive.