【干冰】Anti-LAMP2 (RAT) Monoclonal Antibody - 200-501-G10-【干冰】Anti-LAMP2 (RAT) Monoclonal Antibody - 200-501-G10代理/參數(shù)/廠家-一抗-艾美捷科技有限公司

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中文名稱: 【干冰】Anti-LAMP2 (RAT) Monoclonal Antibody - 200-501-G10

英文名字: 【干冰】Anti-LAMP2 (RAT) Monoclonal Antibody - 200-501-G10

供應商: Rockland

產(chǎn)品貨號: 200-501-G10

產(chǎn)品報價: ￥詢價/100ug

產(chǎn)品說明書: 點擊查看

購買方式: 90%產(chǎn)品中國有現(xiàn)貨庫存。銀行轉賬、電匯、支票、現(xiàn)金，在線支付寶及網(wǎng)銀支付，或直接與我們電話聯(lián)系400-6800-868

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背景資料: Lysosme associated membrane proteins, or LAMP1 and LAMP2, are major constituents of the lysosomal membrane. The two have closely related structures, with 37% sequence homology. They are both transmembrane glycoproteins that are localized primarily in lysosomes and late endosomes. Newly synthesized molecules are mostly transported from the trans-Golgi network directly to endosomes and then to lysosomes. A second pathway involves the lamps being delivered from the Golgi to the cell surface, and then along the endocytic pathway to the lysosomes. A minor pathway involves transport via the plasma membrane. Upon stimulation, a rapid translocation of intracellular LAMPs to the cell membrane is dependent on a carboxylterminal tyrosine based motif (YXXI). If there is a disturbance in this spacing, lysosome localization of LAMP1 is abolished and the mutant protein then cycles between the membrane and the endosome. This stimulation has also been shown to have an associated release of histamine, leukotriene C and prostaglandin D, which shows that LAMP-1 and LAMP-2 are activation markers for normal mast cells. They have also been linked to the inflammatory response in that they promote adhesion of human peripheral blood mononuclear cells (PBMC) to vascular endothelium, and therefore possibly the adhesion of PBMC to the site of inflammation. Anti-LAMP2 antibody is ideal for investigators involved in cytokines, growth factors and cancer research, as well as, Chaperones and Organelle Markers research.

應用類型: IF Microscopy,Immunoprecipitation,Western Blot,

免疫原: LAMP2 Antibody was produced in rat by repeated immunizations with purified preparation of mouse liver lysosomal membranes.

來源宿主: Rat

反應性: Leporidae (Rabbit); Mus musculus (Mouse)

保存建議: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

其他: Rockland成立于1962年，是一家老牌抗體原產(chǎn)企業(yè)，其位于美國費城郊區(qū)的農(nóng)場保有近20種實驗動物。Rockland公司為生命科學領域提供豐富的、高質量的抗體，包括載脂蛋白、細胞周期/凋亡、細胞因子、細胞信號蛋白、酶類、細胞外基質、轉錄因子(NFkB)和泛素（Ubiquitin）等識別抗體，應用范圍包括Western blot、免疫組化、免疫熒光和ELISA等。另外，Rockland也生產(chǎn)特別齊全的二抗，包括純化、生物素、HRP/ALP、熒光標記二抗，應用十分廣泛。