瓦他拉尼,游離堿(25毫克)產(chǎn)品是Cell-permeable. An inhibitor of the VEGFR tyrosine kinases VEGFR-1 (Flt-1, IC?? = 77 nM) and VEGFR-2 (FLK-1/KDR, IC?? = 37 nM), with slightly higher potency against the latter.? At higher concentrations, other tyrosine kinases are also inhibited, including PDGFR-β (IC?? = 580 nM), c-KIT (IC?? = 730 nM), FLT-4 (IC?? = 660 nM) and c-FMS (IC?? = 1.4 uM).? On the other hand, vatalanib is not active against the EGFR, c-SRC, v-ABL, and protein kinase Cα (IC?? > 10 uM).