中文名稱

Troponin-ITC Complex, Porcine, Cardiac

英文名字

Troponin-ITC Complex, Porcine, Cardiac

供應商

USBiological

產(chǎn)品貨號

209281

產(chǎn)品報價

￥1/25ug

產(chǎn)品說明書

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購買方式

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產(chǎn)品新聞

背景資料

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產(chǎn)品描述

Troponins are protein components of striated muscle. Troponin complex is a heteromeric protein consisting of three different subunits-troponin T (TnT), troponin I (TnI) and troponin C (TnC). Each subunit is responsible for a part of troponin complex function which are released only following cardiac damage They are present for, and remain elevated, a long time Unlike CK and CK- MB, cTnT and cTnI are released for much longer with cTnI detectable in the blood for up to 5 days and cTnT for 7-10 days following MI. This allows an MI to be detected if the patient presents late. Troponin T and I are very sensitive. There is always a low level release of CK and CK-MB from skeletal muscle at a low level all the time so there is always a background value. This is not the case for the cardiac structural proteins such as cTnT and cTnI and therefore, they are very sensitive. Studies have revealed that about one third of patients admitted with unstable angina, in which MI was apparently excluded by CK and CK-MB measurement, have raised levels of cTnT and cTnI. Elevation of cTnT or cTnI is absolutely indicative of cardiac damage, but this can occur as a result of causes other than MI e.g. myocarditis, coronary artery spasm from cocaine, severe cardiac failure, cardiac trauma from surgery or road traffic accident, and pulmonary embolus can cause cardiac damage with an accompanying elevation of cardiac troponin(s). Failure to show a rise in cTnT or cTnI does not exclude the diagnosis of ischemic heart disease.Both cTnT and cTnI may be elevated in patients with chronic renal failure and indicate a higher long-term risk of death. They can be distinguished from changes due to myocardial infarction by repeating the tests. Myocardial infarction causes a rise and fall in cTnT or cTnI, but in renal failure the elevated levels are sustained.When calcium binds to the Troponin C it causes conformational changes which lead to dislocation of troponin I and finally tropomyosin leaves the binding site for myosin on actin leading to contraction of muscle. The letter I is given due to its inhibitory character. Troponin complex can used to prepare calibrators and controls for cardiac troponin I assays.Source:Troponin ITC, from porcine cardiac tissuesApplications: Suitable for use in ELISA. Other applications not tested.Recommended Dilution:Optimal dilutions to be determined by the researcher.Storage and Stability:May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

產(chǎn)品形式

該產(chǎn)品為液體形式，緩沖液為：50mM sodium chloride, pH 7.0, 10mM imidazole, 5mM B-mercaptoethanol, 0.1mM calcium chloride, 0.05% sodium azide。

保存建議

接收到Troponin-ITC Complex, Porcine, Cardiac產(chǎn)品后，置于-20°C溫度下保存。

其他

Usbiological公司是美國著名的抗體和生化試劑供應商，生產(chǎn)世界上種類最多的抗體，用于Western Blot、免疫沉淀、免疫熒光、免疫組化和流式細胞術等多種檢測方法。Usbiological公司現(xiàn)已擁有超過50,19234種抗體、抗原和生化產(chǎn)品，為科研用戶提供了諸多超值選擇。

注意

該頁面的中文產(chǎn)品信息的翻譯，僅供參考。準確的產(chǎn)品信息請以廠家的英文說明書為準。下單前，請瀏覽說明書確認。

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