Amidepsine D,Humcola sp。(500 ug)產(chǎn)品是An inhibitor of diacylglycerol acyltransferase (DGAT). Shows inhibitory effect in rat liver microsomes (IC?? = 17.5 uM) and Raji cells (IC?? = 2.8uM). Excessive accumulation of triacetylglycerol produced by DGAT?may cause fatty liver, obesity and hypertriglyceridemia, which may lead to atherosclerosis, diabetes and metabolic disorders.